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Photoacoustic imaging of fluorophores using pump-probe excitation.
Citation key 2015k
Author Märk, Julia and Schmitt, Franz-Josef and Theiss, Christoph and Dortay, Hakan and Friedrich, Thomas and Laufer, Jan
Pages 2522–2535
Year 2015
DOI 10.1364/BOE.6.002522
Journal Biomed Opt Express
Volume 6
Number 7
Month Jul
Institution Institut für Optik und Atomare Physik, Technische Universität Berlin, Strasse des 17. Juni 135, 10623 Berlin, Germany ; Institut für Radiologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Abstract A pump-probe technique for the detection of fluorophores in tomographic PA images is introduced. It is based on inducing stimulated emission in fluorescent molecules, which in turn modulates the amount of thermalized energy, and hence the PA signal amplitude. A theoretical model of the PA signal generation in fluorophores is presented and experimentally validated on cuvette measurements made in solutions of Rhodamine 6G, a fluorophore of known optical and molecular properties. The application of this technique to deep tissue tomographic PA imaging is demonstrated by determining the spatial distribution of a near-infrared fluorophore in a tissue phantom.
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