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Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy.
Zitatschlüssel Pisano2013
Autor Pisano, Tiziana and Spiller, Susan and Mei, Davide and Guerrini, Renzo and Cianchetti, Carlo and Friedrich, Thomas and Pruna, Dario
Seiten 1302–1310
Jahr 2013
DOI 10.1177/0333102413495116
Journal Cephalalgia
Jahrgang 33
Nummer 16
Monat dec
Institution Pediatric Neurology and Neurogenetics Unit, Children's Hospital A. Meyer, University of Florence, Italy.
Zusammenfassung We describe a four-generation Italian family with familial hemiplegic migraine (FHM) and epilepsy due to a novel ATP1A2 missense mutation (R1007W).Mutational analysis revealed a heterozygous nucleotide substitution c.3019C>T resulting in the missense substitution p.Arg1007Trp (p.R1007W) in seven subjects: Three individuals had hemiplegic migraine, two exhibited a clinical overlap between migraine and epilepsy, one had migraine and one was unaffected. The identified ATP1A2 mutation was not found in an ethnically matched control population of 190 individuals and was not reported in a polymorphisms database. In two-electrode voltage-clamp experiments on XENOPUS oocytes, the ATP1A2 R1007W mutant showed (i) reduced ion pumping activity due to a more profound voltage dependence and (ii) decreased apparent affinity for extracellular K? at voltages around the cellular resting potential. This distinct type of loss of function has not been reported for other FHM2 mutations and can lead to impaired K? clearance and elevated K? levels in the CNS.The functional data and clinical evidence suggest that in FHM2 migraine and epilepsy may originate from the same pathogenic mechanisms associated with genetically determined alterations of ion channels and pumps. Our data also support the hypothesis that the new mutation R1007W in our family may be a susceptibility factor for epilepsy.
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